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Chapter 48 Antidysrhythmic Drugs

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Chapter 48 Antidysrhythmic Drugs
Chapter 85
Drug Therapy of Urinary
Tract Infections
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Drug Therapy of Urinary Tract
Infections
• Most common infections
• Upper
– Acute pyelonephritis
– Acute bacterial prostatitis
• Lower
– Acute cystitis
– Acute urethral syndrome
• Recurrent urinary tract infections
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Urinary Tract Antiseptics
•
•
•
•
Nitrofurantoin (Furadantin)
Methenamine (Mandelamine)
Nalidixic acid (NegGram)
Cinoxacin (Cinobac)
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Nitrofurantoin (Furadantin)
• Bacteriostatic—low concentrations
• Bactericidal—high concentrations
• Uses—lower tract UTIs, prophylaxis, recurrent
UTIs
• Adverse effects
– Gastrointestinal effects
– Pulmonary reactions
– Hematologic effects
– Peripheral neuropathy
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Methenamine (Mandelamine)
• Decomposes into ammonia and formaldehyde denaturing
of bacteria
• Uses: chronic lower UTIs
• Adverse effects
– Safe
– Well tolerated
– Contraindicated – Renal patient
– Liver dysfunction
Copyright (c) 2004 Elsevier Inc. All rights reserved.
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